Section: New Results

Affinity Proteomics: Standards for affinity binders

Participants : David James Sherman [correspondant] , Natalia Golenetskaya.

Last year we successfully completed and released the MIAPAR and PSI-PAR international standards for knowledge representation and data exchange of affinity binder properties, a five-year effort organized as part of the ProteomeBinders and HUPO-PSI consortia. These standards were reported in Nature Biotechnology and Molecular and Cellular Proteomics to the research community [3] [37] , [52] and extend previous work [38] , [43] . One long-standing issue is the adoption of these standards by individual researchers in the lab: initial data entry must be simple enough that standards-based reporting can be integrated into the process of writing the paper. We used an extensive dataset of affinity proteomics data to evaluate “last mile” tools for data entry and initial reporting of affinity proteomics data, and identified places where existing tools need to be adapted to meet these specific needs[21] .